| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Assembly of Lipid Bilayers on Hyaluronic Acid Hydrogel Nanoparticles Modified with 1, 2-Ditetradecanoyl-sn-glycero-3-phosphoethanolamine |
| 초록 |
We modified hyaluronic acid (HA) with UV-crosslinkable moieties (methacrylate or 2-aminoethyl methacrylate ) and a lipophilic moiety (1, 2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine (DMPE)), and then prepared hydrogel nanoparticles via a surfactant-free inverse microemulsion method using UV irradiation. The resulting hydrogel nanoparticles had aliphatic lipid chains of DMPE on their outermost surface on which lipid bilayers bearing hydrophobic drug components could be assembled. The loading of a model system was confirmed using a conjugated oligoelectrolyte, cryogenic transmission electron microscopy and spectroscopic techniques. These cross-linked polymeric particles can be applied for transdermal delivery of cosmetics or biomedical delivery. Acknowledge: This work was funded by National Research Foundation of Korea(NRF)(No.20120007432) and the Ministry for Health and Welfare (No.A10301712131330200). |
| 저자 |
윤정주, 박주현, 양진호, 조현진
|
| 소속 |
중앙대 |
| 키워드 |
Hyaluronic acid; DMPE; hydrogel; nanoparticle
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| E-Mail |
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