| 초록 |
Harringtonolide, which is the one of the norditerpenoids derivatives, has been isolated from the Cephalotaxus genus. The derivatives have presented various biological activities such as cytotoxicity towards KB tumor cells, plant growth inhibitory, antiviral and antineoplastic activities. They have a compact tetracyclic structure containing a bridged lactone, tetrahydrofuran ring and consecutive stereogenic centers at a cis-fused tricyclic ring. In order to utilize these biological activities, we have suggested simple and alternative retro-synthetic ways for the synthesis of Harringtonolide. Our new synthetic methods start with a molecule named 6-methoxytetralone with following reaction steps such as Robinson annulation, Bromination and Nitration. Especially, test reactions for demethylation step was performed for developing further reactions. In this study, the optimization of these reactions including demethylation will be illustrated. |
