| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
나노_포스터 |
| 제목 |
LSPR biosensor chip based on glass substrate for high sensitive detection of C-reactive protein |
| 초록 |
Recently, there has been a growing interest in non-labeled biological detection techniques that can be detected without additional sample preparation steps. Here, we demonstrate a simple method for the fabrication of plasmonic-active chip which are uniformly deposited in a single Au layer. The glass based biosensor chip that can be effectively SPR driven was prepared via the control of the chemical ligand concentration, temperature change, and surface modification. As such, we examined the correlation between the enhanced plasmonic effect and surface structure of the resulting substrate to determine the optimum conditions for highly sensitive LSPR sensor chip. To confirm the possibility of the non-labeled LSPR biosensor, we apply it to the quantitative detection of C-reactive protein associated with cardiovascular and renal risk factors. We report a limit of detection for CRP of 10 ng/mL. |
| 저자 |
오서영1, 전태준1, 이은선2, 오미화3, 허윤석2
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| 소속 |
1인하대, 2Animal Production Research and Development Division, 3National Institute of Animal Science |
| 키워드 |
LSPR; CRP; AuNPs; glass substrate; detection
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| E-Mail |
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