| 학회 |
한국화학공학회 |
| 학술대회 |
2004년 가을 (10/29 ~ 10/30, 호서대학교(아산캠퍼스)) |
| 권호 |
10권 2호, p.1240 |
| 발표분야 |
공정시스템 |
| 제목 |
Determining Mass Distributions Considering Natural Isotopes |
| 초록 |
Metabolic flux analysis (MFA) has been a powerful tool for the modeling and analysis of intracellular fluxes and the investigation of biochemical network. By use of gas chromatography-mass spectrometry (GC-MS) for fermentation experiments, it is possible to obtain mass distribution data. However, the correction of mass isotopomer distributions is required because of the occurrence of natural isotopes. In this work, we have developed a mass isotope correction tool, which helps avoid errors in the metabolic flux analysis. The result can provide a precise insight into the complex biochemical network. Acknowledgement This work was supported by IMT-2000 project from MOST and MIC, BK21 project form MOE, and Center for Ultramicrochemical Process Systems sponsored by KOSEF. |
| 저자 |
김상훈, 오영균, 최형석, 김태용, 이동엽, 이상엽, 박선원
|
| 소속 |
Korea Advanced Institute of Science and Technology |
| 키워드 |
Modeling and Simulation; Metabolic Flux Analysis; Isotopomer Distributions; Mass Isotope Correction
|
| E-Mail |
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| 원문파일 |
초록 보기 |
