| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Oxygen nanobubbles for the delivery of mycophenolic acid to modulate a immunosuppression |
| 초록 | Immunosuppressive drugs are crucial for preventing acute graft rejection or autoimmune diseases. They are generally small molecules that require suitable drug carriers for ensuring stability, bioavailability, and longer half-life. Mycophenolic acid (MPA) is an extensively studied immunosuppressive drug. However, it requires suitable carriers for overcoming clinical limitations. Currently, lipid-shelled micro- and nanobubbles are being thoroughly investigated for diagnostic and therapeutic applications, as they possess essential properties, such as injectability, smaller size, gaseous core, high surface area, higher drug payload, and enhanced cellular penetration. Phospholipids are biocompatible and biodegradable molecules, and can be functionalized according to specific requirements. This method can be potentially used for implantation and for treating autoimmune diseases, wherein immunosuppression is desired. |
| 저자 | Muhammad Saad Khan, 황장선, 우현정, 최종훈 |
| 소속 | 중앙대 |
| 키워드 | Oxygen nanobubbles; Mycophenolic acid; Drug-delivery; Immunosuppression |
