| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
고분자구조 및 물성 |
| 제목 |
SYNTHESIS OF POLYASPARTAMIDE ENCAPSULATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES FOR MAGNETIC HYPERTHERMIA THERAPY |
| 초록 |
In this study, we report synthesis of hydrophilic surface and active-target superparamagnetic iron oxide nanoparticles (SPIONs) for hyperthermia cancer therapy. The SPIONs capping oleic acid were prepared by thermal decomposition method. The synthesized SPIONs were encapsulated with the polyaspartamide (PA) to enhance their biocompatibility and hydrophilicity (PA-encapsulated SPIONs). A polysuccinimide (PSI) which is biocompatible and biodegradable is the backbone of PA. In addition, multifunctional polymers including hydrophilic O-(2-aminoethyl) polyethylene glycol (PEG) and hydrophobic octadecylamine (C18) were grafted on PSI for amphiphilic structure, and biotin were conjugated for increasing the cancer cellular uptake. The diameter of the PA-encapsulated SPIONs was confirmed by TEM and DLS. The structure of the PA was confirmed by 1H NMR. The structure and biomedical properties of PA-encapsulated SPIONs were investigated in vitro and in vivo experiments. |
| 저자 |
원민프엉, 김덕준
|
| 소속 |
성균관대 |
| 키워드 |
Hyperthermia; polysuccinimide; superparamagnetic
|
| E-Mail |
|
