| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Direct and Enhanced Coating method of Extracellular Matrix on scaffold using magnesium hydroxide and decellulization for Renal Tissue Regeneration |
| 초록 |
Renal diseases have been recognized as major health issues. In this study, fibroblast-derived extracellular matrix (FDM) was directly coated on three-dimensional porous poly(lactide-co-glycolide) (PLGA) scaffold incorporated with magnesium hydroxide (MH). Optimized decellularization of confluent cells and MH effect resulted in the formation of a well-adhered and high-quality matrix. PLGA scaffold with FDM layer demonstrated significantly increased adhesion and viability of urine derived nephron progenitor cells. For PLGA/MH/FDM scaffolds, enhanced reconstruction of glomerulus was confirmed in a partially nephrectomized mice model with. These results suggest that surface coating of FDM layer using MH would be effective for renal tissue regeneration |
| 저자 |
김윤아1, 전소영2, 유승권3, 권태균2, 한동근4, 정윤기1
|
| 소속 |
1한국과학기술(연), 2경북대, 3고려대, 4차의과대 |
| 키워드 |
renal tissue regeneration; porous scaffold; decellularized extracellular matrix; glomerulus
|
| E-Mail |
|
