| 학회 |
한국화학공학회 |
| 학술대회 |
2008년 가을 (10/23 ~ 10/24, 부산 BEXCO) |
| 권호 |
14권 2호, p.2763 |
| 발표분야 |
생물화공 |
| 제목 |
Identification of nosocomial pathogens using microarray hybridization |
| 초록 |
Nosocomial infections have affected 5% of all patients admitted to hospitals caused 88,000 deaths and accounting for 4.5 billion dollars in health care costs annually. We have developed a diagnostic microarray for the detection of two important nosocomial pathogens, Pseudomonas aeruginosa and Acinetobacter baumannii. The diagnostic microarray contains the DNA probes designed based on the sequences of 23S ribosomal DNA. The microarray was evaluated using reference bacteria as well as various clinical specimens, resulting in the sensitivity of 84.6% and the specificity of 100% for P. aeruginosa, and the sensitivity of 96.2% and the specificity of 100% for A. baumannii. [The work was supported by Medigenes Co. and Korean Systems Biology Research Program (M10309020000-03B5002-00000) of the Ministry of Science and Technology. Further supports by the LG Chem Chair Professorship, KOSEF through the CUPS, IBM-SUR program and BK21 program are appreciated]. |
| 저자 |
유승민1, 장경희2, 유내춘3, 금기창3, 유원민3, 김현욱4, 이상엽1
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| 소속 |
1Dept. of Chemical and Biomolecular Eng., 2KAIST, 3연세대, 4영동세브란스병원 |
| 키워드 |
Nosocomial infection; microarray; probe
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| E-Mail |
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| 원문파일 |
초록 보기 |
