| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
Potentiated Local Immunomodulatory Effect of Uniformly Engineered Hybrid Stem Cell/Drug Depot Spheroids on Xeno-Source Pancreatic Islet Transplantation Outcomes |
| 초록 |
Here, we report a method to potentiate immunomodulatory effect of mesenchymal stem cells (MSCs) by constructing hybrid spheroids with rapamycin-releasing PLGA microspheres (RAP-MS). These hybrids were devised to prevent the strong rejection of xeno-source pancreatic islets. RAP-MS exhibited a narrow size of 4.4 ± 1.7 µm. RAP was sustainably released for 30 days without burst event. Here, the hybrids were rapidly formed in the methylcellulose medium. The hybrids achieved a large size while maintaining high cell viability. Interestingly, RAP-MS were uniformly distributed throughout the hybrids. Importantly, RAP-MS potentiated the effects of MSCs by upregulating pivotal gene expression, thereby improving MSC retention. As the result, these hybrids effectively enhanced islet xenograft survival time after their co-localization under kidney capsule of diabetic mice. We envision that these hybrid spheroids would provide a promising platform for efficient use of MSCs for immunomodulation. |
| 저자 |
응웬티엔티앱1, 박준형1, 쉬레스타먼주1, 팜탄텅1, 박필훈1, 김종오1, 용철순1, 육심명2, 정지헌1
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| 소속 |
1영남대, 2계명대 |
| 키워드 |
Mesenchymal stem cell; rapamycin; microsphere; immunomodulation; islet transplantation; hybrid spheroid
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| E-Mail |
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