| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Fabrication of AB2 miktoarm copolymers micelles for anticancer drug delivery |
| 초록 |
AB2 miktoarm copolymers which mimic structural characteristics of phospholipid are proposed as an alternative to linear copolymers. We synthesized a series of AB2 miktoarm copolymer consisting of PEG as A block and PCL as B block. All synthesized diblock copolymers with fPEG in the range of 0.50 ~ 0.17 formed spherical micelles when they self-assembled in aqueous solution. Contrastively, The PEG-PCL2 miktoarm copolymers with relatively long PCL blocks (fPEG = 0.32 ~ 0.15) formed worm-like micelles in aqueous solution. In the encapsulation study of doxorubicin (DOX) to evaluate their drug loading capacity, Worm-like micelles showed better loading capacity than spherical micelles. In vitro drug release test revealed that both of the DOX-loaded worm-like and spherical micelles displayed sustained drug release patterns, and worm-like micelles exhibited slower release rate than spherical micelles. PEG-PCL2 miktoarm nanocarriers exhibited enhanced cellular uptake into cells compared to DOX. |
| 저자 |
이립1, 윤권혁1, 조하나2, 김보철1, 김용재1, 이은지1, 강한창2, 배유한3, 허강무1
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| 소속 |
1충남대, 2가톨릭대, 3유타대 |
| 키워드 |
miktoarm polymer; PEG; PCL; worm-like micelle; doxorubicin
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| E-Mail |
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