| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.291 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and Release Properties of Self-Emulsifying Drug Delivery System containing Simvastatin |
| 초록 | A self-emulsifying drug delivery systems (SEDDS) was one of the various methods to improve the oral bioavailability of poorly water-soluble drugs, hypercholesterolemia, simvastatin. The optimum formulation (high drug loading, small particle size) of simvastatin SEDDS was as follow: propylene glycol monocaprylate (Capryol 90) of 40% as solubilizers, diethyleneglycol monoethyl ether (Cabitol) of 30% as cosurfactant and polyoxyl 35 castor oil (Cremophor EL) 30% as a surfactant of due to high affinity for the continuous phase. We have been reporting previously the increased bioavailabililty of lovastatin and simvastatin by SEDDS. The release pattern from SEDDS different droplet size was investigated in simulated intestinal fluid. The drug release rate from SEDDS with about 40nm droplet size was more than two-fold faster compared with that of simvastatin tablet and about 150nm droplet size. Acknowledgment: This work was supported by KMOHW (Grant No.; HMP-98-G-2-051-B). |
| 저자 | 윤복영1, 정상영*2, 강길선3, 이해방**, 조선행** |
| 소속 | 1전북대, 2*대화제약, 3**한국화학(연) |
| 키워드 | |
