| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
Biopolymer-Based Hybrid Materials for Sensing and Delivery |
| 제목 |
Cartilage regeneration using a biocompatible hydrogel in vivo |
| 초록 |
Injectable hydrogels may serve as temporary scaffolds to guide cell attachment and differentiation of chondrocytes, resulting in newly formed cartilage tissue. Compared to preformed hydrogels, injectable hydrogels have various advantages. MPEG-PCL diblock copolymers consisting of methoxy polyethylene glycol (MPEG, 750 g/mol) and poly(ε-caprolactone) (PCL) is based on the idea that certain biomaterials undergo a simple liquid-to-gel phase transition under physiological conditions. This hydrogel constructs were then injected subcutaneously in nude mouse and they were retrieved after 1, 2, 4 weeks respectively. The composite hydrogel carried a property of sol–gel transition and thus formed a gel at body temperature. We demonstrated that gelation behavior of hydrogels cross-linked with primary chondrocytes can be controlled by regulating the specific interactions between the polymer and the cells. Hydrogels provided an appropriate environment for cartilage regeneration in vivo. |
| 저자 |
윤소미1, 김다연1, 이빛나1, 이봉2, 민병현1, 김재호1, 김문석1
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| 소속 |
1아주대, 2부경대 |
| 키워드 |
Injectable hydrogel; cartilage; regeneration
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| E-Mail |
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