| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Neurogenic Differentiation of rat Bone marrow Mesenchymal Stem Cells using Small Compounds |
| 초록 |
The aim of our research was thus to identify synthetic chemical molecules that might induce neuronal differentiation of BMSCs. During the course of this screening process, we identified the purine structure-based compounds. Here, we report the first evidence that N-cyclopentyl-N-(4-methoxybenzyl)-9-methyl-9H-purine-2,6- diamine (CMP) and N-(4-methoxybenzyl)-N-methyl-9H-purine-2,6-diamine (MMP) induce neurogenesis of rBMSCs. The larger proportion of NSE- and Tuj1-positive cells relative to CNPase-positive cells as shown by immunostaining suggests that rBMSCs differentiated mainly into neurons. These results support the concept that rBMSCs are potentially a rich source of neurons that can be induced to differentiate using chemical molecules based on familiar chemical series. This work was supported by the Korea Science and Engineering Foundation (KOSEF) funded by the Korea government (MOST, N0. M 1064102000106 N410200110) |
| 저자 |
김이슬1, 김문석1, 강윤미1, 김경해1, 강꽃님2, 박고운1, 김다연2, 이봉2, 김재호1, 윤영필3
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| 소속 |
1아주대, 2부경대, 3대전선병원 |
| 키워드 |
Neurogenesis; rBMSA; small compounds
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| E-Mail |
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