| 초록 |
Adsorption of albumin to biomaterial surfaces has been used in both medical and pharmaceutical applications. It is known that the affinity of albumin increases by grafting of C18 or C16 alkyl chains to the biomaterial surfaces. Brij, which has both long poly(ethylene glycol) (PEG) side chain and stearyl (C18) end group, is specifically designed to get the functional surface to trigger the adsorption of only albumin. In this study, thiol derived Brij (Brij-SH) was synthesized from substituting terminal hydroxyl group of Brij through tosylation, and the Brij-SH was assembled on gold-coated silicon wafer. The obtained assembling material was characterized by surface analysis such as ATR-FTIR, ESCA, SEM, and contact angles and albumin adsorption test. This Brij modified gold surface is useful as nano-scale biosensors for protein chip because it has mobile PEG groups for non-specific protein repulsion and C18 alkyl chains for specific adsorption to albumin.
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