| 초록 |
The fabrication of 3D scaffolds consisting of multi-layered fibrous sheets featuring microchannels is investigated in this work. In this concept, the spontaneous formation of multi-layered scaffold by a single jet electrospinning of a polymeric solution has been reported in previous study. The simple addition of additives; vanadium(III) chloride makes multi-layered structures. Each layer of the sheets allows the diffusion of drugs and other soluble factors to target tissue or organs. Also, these scaffolds have good distribution of the cells as seeding and attaching of the cells occurs on individual layers that are subsequently stacked. Under dynamic conditions, medium flow through the channels improves nutrient availability to the cells on the various layers, drastically increasing cell proliferation on all layers. The physical properties of vanadium doped nanofibrous scaffold were analyzed by mechanical strength and SEM. And assessed the potential as a tissue engineering scaffold. |
