| 학회 | 한국화학공학회 |
| 학술대회 | 2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 | 22권 2호, p.1809 |
| 발표분야 | 생물화공 |
| 제목 | Novel Cisplatin-loaded Peptide Nanostructure as Anticancer Agent |
| 초록 | The cisplatin is one of the anticancer agent using for cancer treatment as platinum-based anticancer material. Also it is showing anticancer effect in variety of cancers (i.e., ovarian cancer, testis cancer, etc.) and solid tumors (i.e., head tumor, neck tumor, etc.). The cisplatin can prevent proliferation of cancer cells by inhibiting cell division and followed by decreasing the size of existing cancer cells. However, the cisplatin has numerous side effects such as ototoxicity, nephrotoxicity, neurotoxicity as well as highly effective anticancer activity. To overcome these limitations, we used tyrosine-rich peptide (YC7) as drug delivery scaffold because of its good bio-stability, and then expected that cytotoxicity was reduced by YC7 peptide. Herein, we developed a cisplatin-loaded peptide nanostructure for nano-drug delivery system driven by gold ion. The resulting cisplatin-loaded self-assembly nanostructure was identified by UV-Vis, TEM, SEM and ICP-OES analysis. To evaluate the efficiency and activity as a novel anticancer drug, YC7@Cis nanostructures were stepwise applied to cancer cellular model and mouse model. Keyword : cisplatin, peptide self-assembly, anticancer agent |
| 저자 | 서재아, 이남훈, 이상명 |
| 소속 | 강원대 |
| 키워드 | 기능성바이오/융합소재공학 |
| 원문파일 | 초록 보기 |
