| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Development of Self-assembled Polymeric Nanoparticles for Drug Delivery Based on Hypoxia-triggered System |
| 초록 |
Hypoxia is an important hallmark of cancer. Due to its unique feature that is rarely seen in normal tissue, hypoxia is being magnified as a primary target in the development of therapeutic drugs. In this study, we attempted to develop hypoxia-sensitive self-assembled nanoparticles which can selectively release the hydrophobic drugs under hypoxic conditions. To prepare hypoxia-responsive nanoparticles (HR-NPs), a hydrophobic 2-nitroimidazole (NI) derivative was conjugated to the backbone of hydrophilic carboxymethyl-dextran. Due to the property of hypoxia-responsive NI derivative, the drug release rate of HR-NPs remarkably increased under the hypoxic condition. In addition, HR-NPs were selectively accumulated at the hypoxic tumor tissues after systemic administration into the tumor-bearing mice. Overall, the HR-NPs might have a potential as the drug carrier for treatments of hypoxia-associated diseases. |
| 저자 |
박재형, 이민창, 한화승, 윤홍열, Thavasyappan thambi, 손소영
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| 소속 |
성균관대 |
| 키워드 |
Hypoxia; bioreduction; drug delivery; carboxymethyl-dextran
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| E-Mail |
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