| 초록 |
A tropoloisoquinoline derivative is a fascinating synthetic target because of its unique fused structure of tropone and isoquinoline rings as well as potent cytotoxicity. The key synthetic step features an oxidative cyclization of a readily available pheonolic nitronate for the construction of the tropoloisoquinoline structure. In addition, a parietropone derivative containing a halogen functional group could be useful for the preparation of various tropoloisoquinolines because it could be easily converted into useful functional groups. Based on this strategy, we will present our effort to synthesize different natural and unnatural tropoloisoquinoline derivatives including isoimerubrine and pareirubrine, natural members of tropoloisoquinolines. |
