| 초록 |
Biodegradable poly(lactide-co-glycolide)(PLGA) have found widespread use in modern medical practice. However, it's degradation rate is relatively slow for soft tissue regeneration especially to restore of skin and mucosa. The purpose of this study is to examine the effect of electron beam irradiation on degradation behavior of PLGA nanofibers. PLGA(50:50) nanofibrous sheets were e-beam irradiated at various doses. The degradation behevior of the nanofibrous PLGA was studied by measuring the changes in weight, FTIR spectra and surface properties. The results showed that morphology of PLGA nanofibrous sheet was not deformed after E-beam irradiation but collapse of surface morphology and weight loss were increased with increasing radiation dose during degradation time. From these results, a hydrolytic degradation is accelerating by electron beam radiation and biodegradation behavior of PLGA nanofibrous scaffolds can be modulated with varying irradiation dose. |
