| 초록 |
This study introduces a new approach to fabricate ceramide microbeads for enhancing epidermal barrier function using hydrophobically modified bacterial cellulose nanofibrils (BCNFs). The core of ceramide beads was structured with a multi-lamellar phase by the co-assembly of ceramide and fatty alcohol, of which surface is armored by C18 alkyl chain-grafted BCNFs. The stability of ceramide beads was affected by chain lengths of fatty alcohol, indicating that longer chain lengths of fatty alcohols further inhibit the formation of the isolated crystalline phase. The content of the grafted C18 alkyl chain on the BCNFs is also critical for the production of stable ceramide microbeads. Finally, we propose that the ceramide microbeads play an essential role in improving skin barrier function by using surfactant-free formulations. |
