| 초록 |
Stratum corneum (SC) lipids have intensively been applied as a component of nanovesicles for enhancing skin barrier function, but the structure of nanovesicles composed of SC lipids is unstable due to high packing parameter of ceramide. Herein, we propose an extremely stable SC mimetic-nanovesicle system in which 1-O-acylceramide (1OA) facilitates tight interaction between the multi-layers of SC model lipid vesicle containing ceramide NP, stearic acid, and cholesterol, thus showing an improved long-term stability. The average size of the nanovesicles was ~ 300 nm and TEM images showed multi-lamellar structure of the nanovesicles regardless of the presence of 1OA. However, SAXS and QCM-D studies revealed that the addition of 1OA in the nanovesicles affects the inter-spacing distance and viscoelastic property of multi-layers, attributed to the acyl chain conformation of 1OA. These findings indicate that 1OA is important for stabilizing the structure of nanovesicles containing SC lipids. |
