| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 | 25권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Targeted photodynamic therapy for hepatocellular carcinoma using pentacyclic triterpenoid derivative |
| 초록 | There are various liver cancer types such as hepatocellular cancer (HCC), cholangiocarcinoma, liver angiosarcoma, etc. Among them, HCC is the most major liver cancer type (＞70%). In this way, researchers are contemplating different approaches to treat HCC. Therefore, we suggest that targeted cancer therapy using photosensitizer (PS). It would be one of the good solutions to problems that we mentioned. We chose HCC targeting moiety which is pentacyclic triterpenoid derivative and conjugate photosensitizer (PS) for photodynamic therapy (PDT). In our experiment, we confirmed targeted-PS molecules are low toxicity and high therapeutic effect through the MTT assay and tumor growth inhibition test. And we observed phototoxicity using Annexin V and PI staining after laser irradiation. From these results, In vitro photodynamic treatment efficacy was good. Consequently, our molecules can be used effectively in various cancer treatment. |
| 저자 | 김홍재, 김지영, 이상희, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Photodynamic therapy; Targeted therapy; Liver cancer |
