| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of Molecular Weights of PVP on the Release Behavior of Sibutramine Solid Dispersion |
| 초록 |
The aim of this study was designed to evaluate properties and dissolution rates of sibutramine solid dispersions by spray drying. Sibutramine as appetite depressant for obesity treatment is soluble in low pH but insoluble in high pH. To improve bioavailability, it should be improve dissolution rate in pH 6.8 because sibutramine is absorbed at the small intestinal track. We investigated effect of molecular weights of PVP on the release behavior of solid dispersion. DSC and XRD were used to analyze the crystallinity of the sample. It was found that sibutramine is amorphous in the solid dispersions. FT-IR was used to analyze the salt formation by hydrogen bond between sibutramine and PVP. As a result of in vitro release behavior, solid dispersion using PVP K30 is obtained good possibility of orally pharmaceutical formulation. This study proposed that this solid dispersion system controlled the release behavior according to molecular weights |
| 저자 |
김용기, 임동균, 홍민성, 이선경, 엄신, 이영현, 유일수, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Sibutramine; solid dispersion; PVP; spray-drying; controlled release
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| E-Mail |
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