| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dissolution Rate improvement with Viscosity of HPMC(Hydroxypropylmethylcellulose) for Sustained release in the Alfuzosin HCl Granule Tablet |
| 초록 |
Hydroxypropylmethylcellulose(HPMC) empolyed in this work is the most widely used polymer as drug delivery system and swelling of HPMC has influence on drug release. Fourier transfer-infrared(FT-IR) used to analyze constitution change of Alfuzosin HCl granule tablet and X-ray diffraction(XRD) used to analyze characteristics of crystallinity. Prepared granule tablet investigated release behavior in the stimulated intestinal fluid (pH 6.8), therefore viscosity of HPMC as excipient could adjust release behavior of Alfuzosin HCl in this study. This study is aimed at finding optimal formation of granule tablet in order to sustain drug release of Alfuzosin HCl, thus the Alfuzosin HCl granule tablet is prepared by viscosity of HPMC. |
| 저자 |
송병주, 김원, 김대성, 김수진, 이선경, 김혜린, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Alfuzosin HCl; HPMC; suspended release; granule tablet
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| E-Mail |
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