| 초록 |
Lipocalins are one of the promising scaffold protein candidate and a model system in scaffold protein engineering. Lipocalins are diverse group of proteins with varied functions, such as transport, pheromone activity, camouflage, immunomodulation, olfaction, enzymatic synthesis and regulation of cell homeostasis. Therefore, understanding the ligand binding modes of these distinctive functional lipocalins will render a clear understanding about the dynamicity of lipocalins for scaffold protein engineering. In this study, we characterized the binding modes of various ligands to lipocalin protein by performing docking studies. Specifically, blind dockings were attempted to understand the specific and nonspecific bindings of ligands, and focussed docking study was carried out to characterize the specific binding of ligands. |
