| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
(생체재료)메디컬용 나노입자 |
| 제목 |
Drug Repositioning of Tauroursodeoxycholic Acid for Bone Tissue Regeneration |
| 초록 |
Bone tissue engineering from bone morphogenetic protein (BMP) and stem cells has been developed with various strategies for enhancement of therapeutic effect. Our recent study found that chemical chaperone tauroursodeoxycholic acid (TUDCA) significantly reduces adipogenesis of mesenchymal stem cells (MSCs). In present study, we examine whether TUDCA as an alternative drug of BMP is able to activate bone tissue regeneration by reducing adipose tissue. It was observed that TUDCA treatment was able to promote in vivo bone tissue regeneration at calvarial defect model and spinal fusion model. In addition, TUDCA treatment significantly decreases apoptosis and inflammatory response in vivo as well as in vitro. The results indicate that TUDCA plays a critical role in not only enhancing in vivo bone regeneration also reducing adipose tissue at implantation site, therefore, would be a potential alternative drug for bone tissue regeneration in pharmacologic and therapeutic applications. |
| 저자 |
이수홍1, 차병현1, 김병주1, Arai Yoshie1, 김병수2, 한인보3
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| 소속 |
1차의과학대, 2서울대, 3차병원 |
| 키워드 |
Drug repositioning; Tauroursodeoxycholic acid; Bone tissue engineering
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| E-Mail |
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