| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Fabrication and evaluation of in situ biodegradable pullulan hydrogels as an injectable hemostatic agent |
| 초록 |
Injectable, biodegradable pullulan hydrogels offer multiple attractive benefits. In this study, the enzyme-mediated injectable pullulan hydrogels containing human plasma components like thrombin were fabricated to use as a hydrogel type hemostatic agent. Its hydrogel has many advantages such as biocompatibility, flexibility, and blood coagulability. The modified pullulan was characterized by ATR-FTIR, 13C NMR and 1H NMR to confirm introduction of tyramines. Gelation, rheological properties were decided as a function of concentration of horseradish peroxidase and pullulan solutions. The in vivo animal testing showed that the modified hydrogel considerably reduced clotting time compared to the unmodified hydrogel. The modified pullulan hydrogel containing blood coagulation agents has adjusted gelation time, biodegradability, hemostatic ability as an effective hemostatic agent of massive blood flow through blood vessels or body parts. |
| 저자 |
이혜영1, 곽동민1, 김현서1, 이승욱2, 권오형3
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| 소속 |
1금오공과대, 2VISION SCIENCE CO., 3LTD. |
| 키워드 |
Hydrogels; Hemostatic agent; Pullulan
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| E-Mail |
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