| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
(여성인재육성위원회) Industry 4.0-에코, 바이오, 에너지-여성과학자가 이끈다 |
| 제목 |
Study of binding mode between various DNA conformation and Ligands |
| 초록 |
The interaction of [Ru(phen)2DPPZ]2+ with a G-quadruplex was investigated. The well-known enhancement of luminescence intensity was observed for the [Ru(phen)2DPPZ]2+ complexes upon formation of an adduct with the G-quadruplex. The emission intensity of the G-quadruplex-bound Λ-isomer was 3-fold larger than that of the Δ-isomer when bound to the G-quadruplex, which is opposite of the result observed in the case of double stranded DNA (dsDNA). Porphyrin (TMPyP) intercalates between the base-pairs of DNA at a low [TMPyP]/[DNA base] ratio in aqueous solutions and molecular crowding conditions, which is induced by the addition of Poly(ethylene glycol) (PEG). According to the LDr (reduced linear dichroism) results of the binding drugs examined in this work, PEG molecules induced no significant change compared to their binding properties in aqueous buffering systems. These results suggest that the transition moments are not expected to be perturbed significantly by PEG molecules. |
| 저자 |
이영애 |
| 소속 |
영남대 |
| 키워드 |
DNA; Lignad; Binding mode
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| E-Mail |
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