| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Peptide film-polypyrrole supported palladium catalyst for one pot aqueous phase synthesis of indole derivatives |
| 초록 |
Indole derivatives have been synthesized for the last decades due to their importance such various biological activities. A well-known approach for synthesizing them is cross-coupling reaction using transition metal catalysts. This can induce one pot synthesis of indolic compounds which is efficient from the green chemistry point of view. However, the method needs harsh reaction conditions. To solve the problem, more efficient catalyst is required. Recently, we have found that tyrosine-rich peptide (TyRP) nanofilm formed at air-water interface can be used as a template for simultaneously inducing polymerizarion of pyrrol and reduction of palladium (Pd) ions. This phenomenon would be attributed to redox property of tyrosine. The TyRP-polypyrrole supported palladium catalysts (TyRP@PPy@Pd catalysts) showed an excellent catalytic activity in one-pot synthesis of indolic compounds which is Sonogashira reaction from 2-iodoaniline derivatives followed by ring-closing reaction in water. |
| 저자 |
김영오1, 유재명2, 장형석2, 정용채1, 이윤식2
|
| 소속 |
1한국과학기술(연), 2서울대 |
| 키워드 |
Peptide; palladium catalyst; indolic compound
|
| E-Mail |
|
