| 학회 |
한국공업화학회 |
| 학술대회 |
2014년 봄 (04/30 ~ 05/02, 제주국제컨벤션센터) |
| 권호 |
18권 1호 |
| 발표분야 |
포스터-콜로이드.계면화학 |
| 제목 |
Tuning the mechanical properties of a skin-mimicking hydrogel with hydrophobic pendant chains |
| 초록 |
There is increasing evidence that matrix stiffness and permeability modulates various phenotypic activities of cells surrounded by a three-dimensional (3D) matrix. This study therefore presents an advanced biomaterial design strategy to regulate the mechanical properties of a 3D hydrogel matrix by introducing hydrophobic micro-domains. Hydrogels were made by cross-linking poly(ethylene glycol) diacrylate (PEGDA) with poly(propylene glycol) methacrylate (PPGMA) acting as a pendant hydrophobic polymer chain. Increasing the mass fraction of PPGMA while keeping the total polymer concentration constant led to a decrease in the elastic modulus (E) of the hydrogel, but caused a minimal increase in the swelling ratio (Q). The micro-domains of the end groups of pendant PPG chains further fine tuned for regulating the encapsulating cells. We believe that this study will significantly contribute to expediting the use of a hydrophobically modified hydrogel in various applications including skin tissue mimicking and replacement. |
| 저자 |
김희진, 이솔이, 정재현, 류희욱
|
| 소속 |
숭실대 |
| 키워드 |
Hydrophobically modified hydrogel; skin tissue
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| E-Mail |
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