| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
BME Release Pattern from β-mercaptoethanol/ Poly(lactic-co-glycolic acid)(BME/PLGA) Scaffolds and Neurogenesis of Bone Marrow Stromal Cells |
| 초록 |
PLGA is a biodegradable polymer with acceptable mechanical strength and well-controlled degradation rate. We fabricated BME/PLGA scaffoldsfor neurogenesis of BMSCs and to observe the release behavior of BME. BME/PLGA scaffold were manufactured as the concentrations of 200,400,600μM,1mM of BME by solvent casting/salt leaching method. Cellular viability and proliferation were assayed by MTT test. Morphology were confirmed by SEM. The effect of BME/PLGA scaffold on the neural differentiation of BMSCs were assessed RT-PCR. The release profiles of BME were assayed using UVspectrometer. Results, BME of 600 μM loaded scaffold revealed low cell viability in the results of MTT. Mophology of BMSCs changed like a neural cell in BME of 200,400μM loaded PLGA scaffold. BME was sustainly released from BME/PLGA scaffolds for 30days. We conclude that neural differentiation of BMSCs in BME/PLGA scaffold could be possible for long period. This research was supported by SCRC(SC4110)and WCU(R31-20029) |
| 저자 |
김혜린, 정수현, 김순희, 김수진, 박현진, 이종문, 강길선
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| 소속 |
전북대 |
| 키워드 |
BME Release; BME/PLGA Scaffolds; Neurogenesis
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| E-Mail |
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