| 초록 |
An elaborate diagnosis of tumor has been studied with the concept of theranostic, for effective tumor therapy. Among which, photosensitizer(PS) is considered because PS has powerful reactive oxygen species(ROS) generation capacity, fluorescence so it can diagnosis and therapy simultaneously. Also, superparamagnetic iron oxide nanoparticles(SPIONs) have been developed with the similar reason of PS. However, PS and SPIONs have some limitations such as low solubility, absence of target ability. We fabricated monocarboxylic acid coated magnetic nanoparticles(MCMNs), with PS and polyethylene glycol linker to overcome these limitations. MCMNs preserve MRI contrast and fluorescence evaluated by relaxation test and confocal laser scanning measurement. MCMNs shows selective internalization aspect to tumor cell in our system. The cytotoxicity of MCMNs controlled under a laser irradiation. These results indicate MCMNs can be a potential theranositc tumor therapy agents. |
