| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Enhanced Dissolution Rate as Ratio of Fenofibrate Solid Dispersion with PVP and/or HPMC |
| 초록 |
Solid dispersion of poor water-soluble drug, fenofibrate, was prepared with poly-N-vinylpyrrolidone (PVP) and hydroxypropyl methyl cellulose (HPMC) E5 to improve the bioavailability. The dissolution rate of solid dispersion was compared with Lipidil Supra® (green cross). In order to investigate the correlation between physicochemical properties and dissolution rate of solid dispersion, the samples were characterized by SEM, DSC and FT-IR. FT-IR was used to analyze the salt formation by interaction between fenofibrate, HPMC E5 and PVP K30. The crystallinity of fenofibrate and solid dispersion was analyzed by PXRD. HPLC was conducted to confirm the dissolution rate of solid dispersion. Thus, the solid dispersion using the spray drying method with HPMC E5 and PVP K30 will have an affect for the bioavailability. This research was supported by NRF-2012M3A9C6050204, Bio-industry Technology Development Program (KMFAFF, 112007-05-2-SB010) and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
이천중, 이현구, 박상미, 송정은, 임동권, 강길선
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| 소속 |
전북대 |
| 키워드 |
Bioavailability; Dissolution rate; Fenofibrate; Solid dispersion
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| E-Mail |
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