| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization and Improved Dissolution Rate as Ratio of Raloxifene Solid Dispersion Using Water Soluble Polymers and acidfier |
| 초록 |
Raloxifene to be affiliated to BCS Class 2 is a poorly water soluble drug. Therefore, this characteristic becomes the cause in which the raloxifene showed the low bioavailability and a lot of difficulties in the process of designing the pharmaceutical formulation. In this study, we prepared solid dispersed raloxifene improved dissolution property in comparison with original drug through the spray drying. The pharmaceutical formulation of solid dispersions was designed by using PVP as water soluble polymer and fumaric, glycoric and citric acid. We analyzed morphological feature of solid dispersion by employing scanning electron microscope (SEM). Crystalline property of solid dispersion was confirmed through X-ray diffraction (XRD). This studies showed that raloxifene have improved dissolution rate in solid dispersion. This research was supported by MIFAFF (112007-05-1-SB010) and the MEST(2012M3A9C6050203). |
| 저자 |
이천중, 김경희, 오승창, 조선아, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Solid dispersion; Dissolution; Raloxifene; Spray-drying; acidifier
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| E-Mail |
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