| 초록 |
Cells typically require appropriate stimulation in tissue engineering approaches, and the effect of physical stimulation on the cell phenotype has been widely investigated for successful tissue regeneration. In this study, we demonstrated that a 3D printable self-healing ferrogel responding to the magnetic field could be fabricated as a tissue engineering scaffold. Ferrogel was prepared from oxidized hyaluronate, glycol chitosan, adipic acid dihydrazide and superparamagnetic iron oxide nanoparticles (SPIONs) via Schiff-base formation. Ferrogel showed self-healing behavior and responded to the magnetic field under physiological conditions. This ferrogel was also 3D printable due to its self-healing properties. Magnetically-actuating scaffold was successfully fabricated using a 3D printer to physically stimulate cells during tissue regeneration. Our approach may provide a useful means to fabricate tissue engineering scaffolds that can regenerate tissue or organ under dynamic conditions. |
