| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Effect of porosity in alginate hydrogels on the drug release behavior. |
| 초록 |
In this study, two kinds of alginate-based hydrogel were prepared: alginate-furfuryl amine (Alg-F) crosslinked by disulfide-maleimide (S-Ma) and alginate-norbornene (Alg-Nb) crosslinked by disulfide-tetrazine (S-Tz). The “click” chemistry between Alg-Nb and S-Tz during gelation was producing N2 gas and led to the formation of hydrogels with porous structure, in which the porosity could be tuned by adjusting the proportion of crosslinker. As for the crosslinking reaction between Alg-F and S-Ma was performed by DA reaction, which did not produce any by-product and led to the formation of non-porous hydrogel. The drug release study revealed that hydrogel porosity affected drug loading capacity and played a significant role in the kinetics of drug release. In addition, the porous alginate hydrogel exhibited steady drug release for 35 days in a sustained manner. |
| 저자 |
조성우, Sonita Afrita Purba Siboro, 이시윤, 박찬, 임권택
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| 소속 |
부경대 |
| 키워드 |
alginate hydrogels; drug release; porosity
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| E-Mail |
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