| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dissolution Characterization and Improvement of Aceclofenac Solid Dispersion with Water Soluble Polymer |
| 초록 |
Aceclofenac is anti-inflammatory drug and is poorly soluble drugs of insoluble in water. Aceclofenac almost insoluble in water as soluble drugs due to low absorption of the drug in the body it is experiencing many difficulties medicine formulation. In this study, we prepared solid dispersions using the spray in addition drying used plasdone® C-15 of water solubility polymer and confirmed dissolution characteristics with improvement of drugs. Determination of solid dispersion was measured to evaluate the differential scanning calorimetry (DSC), x-ray diffraction (XRD). Fourier transform infrared spectroscopy (FT-IR) was used to analyze chemical changes of solid dispersion. These results aceclofenac increased the surface and improved the dissolution rate. This research was supported by WCU (R31-20029). |
| 저자 |
심정보, 조원형, 이윤미, 임동균, 유석철, 오명준, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Solid dispersion; aceclofenac; improvement of dissolution; PVP
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| E-Mail |
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