| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
대학원생 구두발표(발표15분) |
| 제목 |
Controlled Clustering of Anisotropic Bimetal-polymer Composite Nanostructures for Multiplexed Biosensing |
| 초록 |
Anisotropic inorganic-organic composite nanostructures have unique optical properties and physicochemical characteristics at each compartment. Especially, surface-enhanced Raman scattering (SERS) has great potential for biochemical detection with high sensitivity and multiplexing capabilities. We report herein that anisotropic bimetal-polymer composite nanostructures were formed via oxidation-reduction, and their directionally clustered architectures composed of bimetal Au-Ag core and poly(aniline) shell were formed by interparticle coupling via hydrophobic interactions. These clusters as SERS nanoprobes were used for multiplexing of autoantibodies in the early diagnosis of rheumatoid arthritis. Sandwich-type immunocomplexes composed of SERS nanoprobes, the autoantibodies and magnetic beads were formed, and multiplexed detection of the autoantibodies was achieved. Conclusively, these clustered architectures would be promising as advanced functional nanoprobes for SERS-based biosensing. |
| 저자 |
황은영1, 임동우2
|
| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ. |
| 키워드 |
Anisotropy; Bimetals; Directional clustering; Surface enhanced Raman scattering; Biosensing
|
| E-Mail |
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