| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Oxygen-generating glycol chitosan-manganese dioxide nanoparticles enhance the photodynamic effects of chlorin e6 on activated macrophages in hypoxic conditions |
| 초록 |
This study aimed to investigate the use of glycol chitosan (GC) for the synthesis of MnO2 nanoparticles (NPs) and to evaluate whether the prepared GC-MnO2 NPs enhace the light-triggered photodynamic effects of chlorin e6 (Ce6) via the generation of oxygen and alleviation of hypoxia in lipopolysaccharide (LPS)-actovated marophages (RAW 264.7), which produce excessive amounts of reactive oxygen species (ROS). GC-MnO2 NPs were synthesized by a simple reaction between GC and KMnO4 in water. The prepared GC-MnO2 NPs were spherical in shape, with a mean diameter of apporximately 60 nm. The particles effectively generated oxygen via H2O2-induced degradation nuder hypoxic conditions, which led to an increase in the singlet oxygen levels upon laser irradiation. |
| 저자 |
홍지연, 박경순, 임용근, 민지선, 안재원
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| 소속 |
중앙대 |
| 키워드 |
Glycol hitosan; Manganese dioxide; Photodynamic effect; Hydrogen peroxide; Hypoxia; Activated macrophages
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| E-Mail |
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