| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Engineered magnetic nanoclusters for sensitive diagnosis of atherosclerosis via magnetic resonance imaging |
| 초록 |
Oleyl dextran-coated magnetic nanoclusters (ODMCs) were fabricated for magnetic resonance (MR) imaging of atherosclerotic plaques. We synthesized ODMCs by enveloping magnetic nanocrystals (MNCs) as MR probes with conjugates of hydrophobic oleic acid and hydrophilic dextran, which is known to specifically bind to macrophages through scavenger receptors (ODex). The magnetic properties of ODMCs were engineered by control degree of substitution (DS) of oleyl group in ODex and the concentration of ODex used for coating of MNCs. Engineered ODMCs exhibited high MR sensitivity and efficient targeting ability against macrophages without cytotoxicity. In vivo MR imaging after intravenous injection of ODMCs into a rat balloon injury model showed considerable decrease of MR signal intensity at plaques of the injured carotid artery. From these results, we verified that ODMCs have sufficient potential as a MR imaging agent for diagnosis of atherosclerosis. |
| 저자 |
김명훈, 김봉준, 임은경, 최지혜, 최유나, 서진석, 허용민, 함승주
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| 소속 |
연세대 |
| 키워드 |
Magnetic nanoclusters; Magnetic resonance imaging; Atherosclerosis; Dextran; Macrophage
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| E-Mail |
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