| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Development Hybrid Scaffold Using Bladder Submucosa Matrix and Alginate |
| 초록 |
In this study, we prepared BSM-alginate hybrid scaffolds, investigated basic properties such as morphology and cell viability, and evaluated their function with human skeletal muscle cells (hSkMCs) in vivo, considering their utility as scaffolds for muscle regeneration. The 135 proteins are in BSM. Porosity of the scaffold was reduced by incorporating BSM, suggesting the density of scaffold was increased. Excellent cell viability and cytocompatibility of alginate scaffold was maintained in the case of BSM-alginate scaffold. The immunofluorescence and immunochemical staining of the BSM-alginate scaffolds implanted with hSkMCs in subcutaneous spaces of balb/c-nude mice confirmed that the presence and the migration of cells and tissues, as well as the structural stability of scaffolds in vivo, were predominant as compared with the alginate scaffolds. |
| 저자 |
최진현1, 임현주1, 정호윤2, 전소영1, 권태균3, 임정옥1
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| 소속 |
1경북대, 2국제재생(연), 3국제재생의학(연) |
| 키워드 |
Bladder submucosa matrix; alginate; scaffold; muscle regeneration
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| E-Mail |
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