| 초록 |
There is growing interest in theranostic nanomedicine with integrated imaging and therapeutic modalities for simultaneous diagnosis, disease treatment, and monitoring of therapeutic efficacy. In particular, surface-enhanced Raman scattering (SERS) technology with high sensitivity and multiplexing capabilities is emerging as a powerful alternative for identifying specific biological targets in live cells. In this study, we synthesized novel SERS-active gold nanochains (AuNCs). Raman reporters and photosensitizers (PSs) were conjugated onto the surface of the AuNCs for multiplex detection and PDT action. Folic acid also was introduced to the nanochain for active targeting. The optical property and morphology of HA-based AuNCs were investigated. We also investigated their biocompatibility, cellular localization property, and phototoxicity against MCF 7 and A549 cells. |
