| 초록 |
In recent years, theranostics, the integration of therapeutic and diagnostic capability in a single system, has gained considerable attention as the next generation of medicine that will enable early detection of diseases, as well as simultaneous monitoring and therapy with minimal toxicity. Especially, SERS technology with high sensitivity and multiplexing capabilities is emerging as a powerful alternative for identifying specific biological targets in live cells. In this study, Raman reporters and photosensitizers were conjugated onto the surface of the gold nanochains (AuNCs) for imaging and PDT of tumor cells. Tumor-targeting ligand was also introduced to the AuNCs as an active targeting linker. The photophysical properties of AuNCs in aqueous solution and morphology were determined. In addition, in vitro cellular localization, singlet oxygen generation and phototoxicity of SERS-active AuNCs were investigated using MCF7 and A549 cells. |
