| 초록 |
In this study, a NIR-triggered upconversion nanoparticles was used to treat cancers at a deep tissue level. A major drawback in the current PDT is the limited penetration depth due to the light absorption and scattering by biological tissues, resulting in ineffective therapeutic effects. Recently, the upconversion nanoparticles (UCNPs) opened a new gate for full utilization of currently commercial available PS upon NIR irradiation. Herein, we synthesized UCNPs by hydrothermal method and employed folic acid-conjugated biocompatible block copolymers to improve their stability. Then, high efficient commercial PSs were conjugated to the stable UCNPs. The composition, optical property and morphology of UCNP-based nanomedicine were investigated. Cellular uptake and phototoxicity against MCF 7 and A549 cells under 980nm laser irradiation were also investigated. |
