| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
The Improved Dissolution Rate of Lercanidipine Using Spray Drying and Rotary Evaporator with PVP K-30 |
| 초록 |
In order to improve the poorly water solubility of lercanidipine, we prepared solid dispersion for improvement of dissolution rate by using spray drying and rotary evaporator. It was formulated by arranging ratios of poly-vinyl-pyrrolidone (PVP). Characterization of solid dispersion was analyzed by using SEM, DSC, XRD and FT-IR. SEM and FT-IR were used to analyze morphology and salt formation by chemical bond between lercanidipine and polymer. The in vitro release behavior of solid dispersion conducted in simulated gastric juice (pH 1.2). This study suggested that the amounts of added polymers affected the dissolution rate and two solid dispersion system improved the bioavailability of lercanidipine. This research was supported by NRF-2012M3A9C6050204, Bio-industry Technology Development Program (KMFAFF, 112007-05-2-SB010) and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
양재원, 정현기, 고현아, 장나금, 김은영, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Lercanidipine; solid dispersion; spray drying; rotary evaporator; PVP
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| E-Mail |
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