| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Sirolimus-eluting stent coated by ultrasonic spray and controlled drug release |
| 초록 |
One of the solutions about in-stent restenosis and late thrombosis is to use drug that can prevent tissue hyperplasia followed by vascular injury in coronary stent. Sirolimus (SRL) is a popular drug for this purpose. In this study, SRL-loaded polymer coating on stent was carried out by ultrasonic spraying. In particular, top coating was applied for the control of SRL release from stent. In ultrasonic spraying, factors such as vibration frequency, gas pressure and solution concentration, were dominant in controlling the coating thickness and smoothness. From FE-SEM images, it was confirmed that the thickness of polymer layer was 5±1 m. The loading amount of SRL was 100 μg/cm2. It was clear that top-coating and solvent system affected release behavior of SRL. Depending on the thickness and/or type of polymers, top-coating on drug-in-polymer layer produced significantly different release profiles. Solvent system influenced the release kinetics as well. |
| 저자 |
장부남1, 최지연1, 강종희1, 박귀덕1, 노인섭2, 한동근1
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| 소속 |
1한국과학기술(연), 2서울과학기술대 |
| 키워드 |
ultrasonic spray; sirolimus; controlled drug release; solvent system
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| E-Mail |
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