| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Synchrotron X-ray Bio-imaging of Bone Regeneration by Artificial Bone Substitute Composed of MGSB and HA hydrogels |
| 초록 |
Artificial bone substitute of bioactive MegaGen synthetic bone (MGSB) and hyaluronic acid (HA) hydrogels was successfully developed for bone tissue engineering applications. On the basis of the fact that HA plays important roles in bone regeneration and promotes the differentiation, vascularization, and migration of stem cells, HA hydrogel was designed to supply HA continuously for effective bone regeneration by its controlled degradation in vivo. MGSB composed of hydroxyapatite (60 wt%) and -tricalcium phosphate (40 wt%) was prepared by the chemical precipitation method with a porous spherical morphology. After implantation in the calvarial critical size bone defects of New Zealand white rabbits for 8 weeks, MGSB/HA-Cystamine hydrogels resulted in excellent bone regeneration according to histological analysis. In addition, synchrotron X-ray imaging clearly visualized 3-dimensional micron scale morphologies of regenerated bones being interconnected with the bone substitute. |
| 저자 |
염준석1, 장소은1, 박정규1, 제정호1, 양동준2, 최석규2, 한세광1
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| 소속 |
1POSTECH, 2Megagen |
| 키워드 |
Hyaluronic acid; Hydrogel; Megagen synthetic bone; Bone regeneration; X-ray bioimaging
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| E-Mail |
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