| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Radiopaque & Biodegradable Polymeric Microparticle for Transarterial Chemoembolization |
| 초록 |
Transarterial Chemoembolization (TACE) is one of methods for treating hepatocellular carcinoma, which occludes the hepatic artery with micro-beads or viscous oils mixed with anticancer drugs. TACE is surgical operation-free method, induces less pain and demands short treatment time. The embolic materials, which designate matters used for TACE, should exhibit several characteristics such as x-ray visibility for operational convenience, biodegradability for repetitive injection, and mechanical strength enough to endure blood stream. In this research, we formulated well-calibrated micro-sized particle with FDA-approved biodegradable polymer and the radiopacity was given to microparticle during the particle formation for convenience and safety of treatment. The particle size was analyzed with optical microscope and the content of radiopaque substituent was determined by 1H NMR. In conclusion, we confirmed the potential of this biodegradable polymeric bead for more effective cancer therapy. |
| 저자 |
전성익1, 안철희2, 이명수3, 김영일4, 제환준1
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| 소속 |
1Research Institute of Advanced Materials (RIAM), 2Department of Materials Science and Engineering, 3College of Engineering, 4Seoul National Univ. |
| 키워드 |
Microparticle; Embolic Material; Transarterial Chemoembolization
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| E-Mail |
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