| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.378 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Sustained release of nifedipine from multi-coated bead containing porous membrane and various excipients |
| 초록 | Such oral delivery systems are based on osmosis, the diffusion of water transversely a semi-permeable membrane from a medium with a low osmotic pressure to a medium with a high osmotic pressure. For the improvement of release pattern and water-insolubility of nifedipine (ND), we prepared osmotic multi-coated beads by fluidized-bed spray coating method. The present study is intended as an investigation of the effect of different preparation factors, such as bead sizes, membrane thickness and excipients for optimal release performance. Based on the results of in vitro release test, ND beads release rate were associated with membrane thickness, bead sizes, such as the smaller beads has been fast release rate than the bigger, and the amount of excipients, such as disintegrant and binder. It has been significantly improved in the release rate, and the purpose of delivering water-insoluble ND at an approximate zero-order release profile for 24 hours, osmotic beads has been successfully prepared. Table. 1. The composition of multi-coated beads Fig. 1. The release profiles of Fig. 2. The image of multi-coated beads multi-coated beads Reference 1. R.K. Verma, B. Mishra and S. Garg, Osmotically controlled oral drug delivery, Drug Dev. Ind. Pharm. 26, 695, (2000) 2. L. Liu, G. Khang, J.M. Rhee and H.B. Lee, Monolithic osmotic tablet system for nifedipine delivery, J. Control. Release 67, 309, (2000) |
| 저자 | 전세강1, 채강수1, 조영호1, 김문석2, 조선행2, 강길선1, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | nifedipine; multi-coated bead; porous membrane |
