| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Effect of Lysophosphatidic acid-loaded Silk Film for Cornea Endothelium Regeneration |
| 초록 |
Lysophosphatidic acid(LPA) is known as a multifunctional intercellular phospholipid messenger. Since, LPA can act as a signaling molecule, it favours cell growth. Because of its good biocompatibility and easy processing, silk fibroin (SF) is used as a tissue engineering scaffold. LPA/SF scaffolds were fabricated with 0µM and 20µM LPA loadings. Fabricated LPA/SF scaffolds loaded 0µM and 20µM were analyzed for various properties such as FESEM, contact angle, transparency, FTIR, MTT assay, mRNA expression, etc. 20µM loaded LPA/SF scaffolds displays good cell proliferation and morphology. LPA/SF scaffolds were found to support cell growth and forms hexagonal morphology with well-maintained bio-functions. Thus, the LPA/SF scaffolds can be envisioned as a highly-suitable material for cornea transplantation with good water mobility |
| 저자 |
국연지, 전하얀, 심보라, 전유신, 최주희, 신은영, 송정은, 강길선
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| 소속 |
전북대 |
| 키워드 |
Silk fibroin; Lysophosphatidic acid; Cornea regeneration; Cornea endothelial cells
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| E-Mail |
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